Conclusion : through promoting hfcl proliferation and acting on multiple protein targets , the blood enriching function of ligustrazine can be exerted indirectly 結(jié)論:川芎嗪能促進(jìn)入骨髓成纖維樣基質(zhì)細(xì)胞增殖,作用于多個(gè)蛋白質(zhì)靶點(diǎn),間接發(fā)揮補(bǔ)血作用。
Proteinmicroarrays are now becoming very popular due to their possible futureapplications in the study of nucleic acid - protein , protein - protein , ligand - receptor , drug - protein target , and enzyme - substrate interactions 蛋白芯片正在成為相當(dāng)受歡迎,由于他們的未來可能應(yīng)用在研究核酸蛋白、蛋白質(zhì),配體受體藥物靶蛋白和酶基板互動(dòng)
If the proteins targeted by new drugs turn out to differ from one tumor to the next or to vary within a tumor during the course of its growth or treatment , this heterogeneity will make it difficult to get therapies that target blood vessels to work on their own 如果說新藥所瞄準(zhǔn)的蛋白質(zhì)在不同腫瘤的表現(xiàn)有所差異,或是在同一腫瘤的不同生長(zhǎng)或治療期間有所變異的話,那麼針對(duì)血管的療法就很難達(dá)到療效。
The scfco , " ubiquitin - ligase complexes are required for jasmonate response in arabidopsis ( l ) arabidopsis coi is required for all the jasmonate - regulated response . it encodes a protein containing leucine - rich repeats and a degenerate f - box motif these structural features are characteristic of f - box proteins that function in ubiquitin ligase complexes for the ubiquitylation of substrate - proteins targeted for degradat1on 以表達(dá)融合蛋白flag - coi1的擬南芥為材料,用- flag抗體進(jìn)行免疫共沉淀分析發(fā)現(xiàn), coi1蛋白可以與ask1 、 ask2 、 atrbx1和atcul1蛋白結(jié)合形成scf ~ ( coi1 )復(fù)合體,并發(fā)現(xiàn)其中的atcul1蛋白包括未修飾和修飾的兩種形式。